Mondino M, Haesebaert F, Poulet E, Suaud-Chagny M-F, Brunelin J. PET imaging and cognition in schizophrenia. įrith C, Friston K, Liddle P, Frackowiak R. Cognitive phenotype and psychiatric disorder in 22q11.2 deletion syndrome: a review. What are the neurocognitive correlates of basic self-disturbance in schizophrenia?: integrating phenomenology and neurocognition. Nelson B, Whitford TJ, Lavoie S, Sass LA. Neurocognitive predictors of source monitoring in schizophrenia. Preliminary evidence of an interaction between the FOXP2 gene and childhood emotional abuse predicting likelihood of auditory verbal hallucinations in schizophrenia. McCarthy-Jones S, Green MJ, Scott RJ, Tooney PA, Cairns MJ, Wu JQ, et al. P.3.a.007 FOXP2 gene possibly associated with Korean schizophrenic patients. FOXP2 gene and language impairment in schizophrenia: association and epigenetic studies. Tolosa A, Sanjuan J, Dagnall AM, Molto MD, Herrero N, de Frutos R. Association between FOXP2 polymorphisms and schizophrenia with auditory hallucinations. Sanjuan J, Tolosa A, Gonzalez JC, Aguilar EJ, Perez-Tur J, Najera C, et al. FOXP2 and the neuroanatomy of speech and language. Vargha-Khadem F, Gadian DG, Copp A, Mishkin M. A forkhead-domain gene is mutated in a severe speech and language disorder. Lai CS, Fisher SE, Hurst JA, Vargha-Khadem F, Monaco AP. Adaptive evolution of genes underlying schizophrenia. MR and genetics in schizophrenia: focus on auditory hallucinations. 2009 43(1):13–24.Īguilar EJ, Sanjuan J, Garcia-Marti G, Lull JJ, Robles M. Is schizophrenia the price of human central nervous system complexity? Aust N Z J Psychiatry. Schizophrenia as the price that Homo sapiens pays for language: a resolution of the central paradox in the origin of the species. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. schizophrenia research forum, schizophrenia research forum. Biological insights from 108 schizophrenia-associated genetic loci. Schizophrenia Working Group of the Psychiatric Genomics C. Auditory hallucinations: a review of psychological treatments. Auditory hallucinations in schizophrenia and nonschizophrenia populations: a review and integrated model of cognitive mechanisms. Waters F, Allen P, Aleman A, Fernyhough C, Woodward TS, Badcock JC, et al. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. 2005 162(10):1824–32.Īllen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, Khoury MJ, et al. Relationship between a high-risk haplotype in the DTNBP1 (dysbindin) gene and clinical features of schizophrenia. 2015 30(4):486–91.įanous AH, van den Oord EJ, Riley BP, Aggen SH, Neale MC, O’Neill FA, et al. Dysbindin (DTNBP1) variants are associated with hallucinations in schizophrenia. The complexity of genetic interactions with respect to the pathophysiology of auditory hallucinations is in need of further discourse and scientific elucidation. These studies should be aimed at uncovering links between neurobiological parameters of auditory hallucination and gene-gene/gene-environment interactions. Future research with more robust methodology should replicate the present genetic findings as many of the present studies are limited by small sample size. The key genes that have been implicated include FOXP2, dystrobrevin-binding protein 1 ( DTNBP1), dopamine system genes, cholecystokinin, serotonergic genes, as well as microdeletion of the long arm of 22q11.2 chromosome. The proposed theoretical bases for hallucinations and their relevant neural substrates in the context of specific genes are discussed-these include language pathways, source monitoring deficits, aberrant salience, and dysregulated emotional valence. This chapter attempts to summarize the existing literature in the domain of genetic basis of auditory hallucinations in schizophrenia.
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